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FBXW7 controls proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, Notch and AURKA. Consistent with the tumor suppressor role of FBXW7, it is located at chromosome 4q32, a genomic region deleted in more than 30% of all human cancers (Spruck CH et al., Cancer Res 62:4535-9, 2002).

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WASHINGTON (AP) — On a brisk, damp night that hinted of October, Washington Nationals starter Gio Gonzalez pitched like a man determined to make an impact in the playoffs.

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